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    • (PDF) The glutaminase activity of L

      Gary L. Gilliland Alexander Wlodawer The amino acid sequence and tertiary structure of Wolinella succinogenesl-asparaginase were determined, and were compared with the structures of other type-II ...

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    • Structural Insight into Substrate Selectivity of Erwinia ...

      2019-5-25 · The crystal structure of E. coli asparaginase II (EC 3.5.1.1), a drug (Elspar) used for the treatment of acute lymphoblastic leukemia, has been detd. at 2.3 Å resoln. by using data from a single heavy atom deriv. in combination with mol. replacement. …

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    • Structural Insight into Substrate Selectivity of Erwinia ...

      2019-5-25 · l-Asparaginases of bacterial origin are a mainstay of acute lymphoblastic leukemia treatment. The mechanism of action of these enzyme drugs is associated with their capacity to deplete the amino acid l-asparagine from the blood. However, clinical use of bacterial l-asparaginases is complicated by their dual l-asparaginase and l-glutaminase activities.

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    • ELISA to evaluate plasma anti-asparaginase IgG ...

      Of 169 patients (41.2%) with clinical allergy, 147 (87.0%) were positive for anti-Elspar antibody. Of 241 patients without allergy, 89 (36.9%) had detectable antibody.

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    • Stability of L-asparaginase: An enzyme used in leukemia ...

      Elspar ®, a commercial L-asparaginase has a high activity restoration capacity when submitted to optimum temperatures (37 o C), in pH 8.6 buffer, and surprisingly, in physiologic solution [46]. ...

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    • (PDF) L-Asparaginase: An Effective agent in the treatment ...

      Abstract L-asparaginase (L-ASNase) is one of the most effective enzyme used in the treatment of ALL for more than 30 years. It catalyzes the hydrolysis of amino acid L-asparagine to aspartic acid ...

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    • (PDF) The glutaminase activity of L

      The best evidence supporting amino acid vulnerabilities for the treatment of leukemias is based on the efficacy of the chemotherapeutic L-asparaginase (58-63), which is a bacteriaderived enzyme ...

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    • Stability of L-asparaginase: An enzyme used in leukemia ...

      The enzyme from Erwinia carotovora showed maximum activity at pH 8.0 and at 50 o C [45], while the commercial preparation of Lasparaginase, Elspar ® (isolated from E. coli), was found to be ...

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    • The eIF2 Kinase GCN2 Is Essential for the Murine Immune ...

      Introduction. Asparaginase (ASNase) 7 is an effective treatment for acute lymphoblastic leukemia, the most common childhood cancer ().ASNase catalyzes the hydrolysis of amino acid asparagine to aspartic acid and ammonia, exploiting an Achilles heel in the leukemic lymphoblast, low or absent levels of asparagine synthetase (ASNS) ().The potency of the drug to induce cell death is a consequence ...

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       · БЛОГ ЗА БЪЛГАРСКАТА ПОЛИТИКА И ПОЛИТИЦИ :: Нова професия - професионален оплювач във форумите В България критиката в интернет също може да донесе пари, обяснява пък пред българската редакция на "Дойче веле ...

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      Utilisez-en la moitié en les concassant au creux de la main pour les émietter et ajoutez-les à la sauce (gardez l''autre moitié pour décorer le plat). Vous pouvez aussi ajouter des noix de cajou ou des cacahouètes grillées émiettées au couteau, de la ciboulette ou du persil émincé. Le tout c''est que la sauce devienne assez compacte.

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    • (PDF) Alanyl-Glutamine Consumption Modifies the ...

      LO, Al drich CJ, Durde n DL, et al. Ro le of glutam ine depl etion in dire cting tissue -spec ific nutr ient stress respon ses to L- aspara gina se. J Biol Chem. 2006;2 81:31 222–33 .

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